RESUMO
The binding characteristics of Thyroxine Binding Globulin(TBG) Pre-albumin (TBPA) and Transcortin in Jamaicans were found to be similar to those described elsewhere. The previously reported diminution in adrenocortical and thyroidal function associated with normal plasma cortisol and thyroxine levels cannot therefore be ascribed to an increase in the plasma protein binding of these hormones (AU)
Assuntos
Feminino , Humanos , Gravidez , Pré-Albumina/metabolismo , Ligação Proteica , Albumina Sérica/metabolismo , Proteínas de Ligação a Tiroxina/metabolismo , Transcortina/metabolismo , JamaicaRESUMO
Thyroid function has been investigated in 32 hospitalized euthyroid Jamaicans. The in vivo investigations performed were measurement of 2«, 4 and 24 hr thyroidal uptake of 131I, thyroidal and renal clearances of radioiodide, absolute iodide uptakes and, in 6 subjects, radiothyroxine turnover studies. Thyroxine binding globulin and prealbumin capacities were measured in a small number of cases. Results obtained in all these investigations agreed well with those found in temperate climates and are at variance with previous finding of low 24 hr thyroidal uptakes of 131I in euthyroid Jamaicans, associated with a normal serum protein-bound iodine.(AU)
Assuntos
Humanos , Glândula Tireoide/fisiologia , Testes de Função Tireóidea , Radioisótopos do Iodo , Jamaica , Rim/fisiologia , Testes de Função Tireóidea , Tiroxina/sangue , Tiroxina/metabolismo , Proteínas de Ligação a Tiroxina/análise , Medicina TropicalRESUMO
In 1964 Goldberg et. a.l reported the results of a thyroid function study in a large group of normal Jamaicans. Very low 24 hour thyroidal uptakes of I131 were obtained, the mean being 13.8 percent of the dose. In view of these findings thyroid function was reassessed in 32 euthyroid Jamaican subjects. Investigations performed included, estimation of plasma inorganic iodide, 2, 4, and 24 hour thyroidal uptakes of radio iodide, absolute thyroidal iodide uptake and thyroidal and renal clearances of plasma iodide. Results obtained in all these investigations agreed well with those found in temperate climates and are at variance with the findings of Goldberg et al (AU)
Assuntos
Humanos , Adulto , Testes de Função Tireóidea , Iodo , JamaicaRESUMO
The case is presented of a 69-year-old woman with a long standing lesion at the base of the brain who terminally developed the classical findings of the inappropriate secretion of antidiuretic hormone. It is postulated that the lesion, in close proximity to the pituitary stalk, could have acted as an irritative focus, resulting in over-production of antidiuretic hormone (AU)
